Prof. Dr. med. Robert Grosse
Qualifications and history
1998 | MD, Free University Berlin, Benjamin Franklin Campus |
1994-99 | Doctoral thesis, Institute of Pharmacology, Free University Berlin |
2000 | Postdoctoral fellow (EMBO Fellow), London Research Institute (LRI), UK |
2004 | Emmy Noether Group leader, University of Heidelberg, Medical Faculty |
2009 | Habilitation and Medical Specialization (Facharzt) in Pharmacology, University of Heidelberg |
2009 | Full professor and chair, Institute of Pharmacology, University of Marburg, Medical Faculty |
2019 | Full professor and chair, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Medical Faculty |
Honors and Awards
2023 | Member of the German National Academy of Sciences Leopoldina |
2016 | HFSP (Human Frontiers Science Program) lead investigator of program grant |
2013 | Binder-Innovation Prize of the German Society of Cell Biology |
10 Selected Publications
Krippner S, Winkelmeier J, Knerr J, Brandt DT, Virant D, Schwan C, Endesfelder U, Grosse R (2020) Postmitotic expansion of cell nuclei requires nuclear actin filament bundling by α-actinin 4. EMBO Rep, 21, e50758, 1-11
Abstract
Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, Hüttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, Félix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, García-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell, 182, 685-712
Abstract
Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R (2019) GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun, 10, 5271, 1-9
Abstract
Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017) A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nat Cell Biol, 19, 1389-99
Abstract
Hinojosa LS, Holst M, Baarlink C, Grosse R (2017) MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol, 216, 3087-95
Abstract
Grikscheit K, Frank T, Wang Y, Grosse R (2015) Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol, 209, 367-76
Abstract
Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell, 4, 475-83
Abstract
Baarlink C, Wang H, Grosse R (2013) Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science, 340, 864-7
Abstract
Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin. Nat Cell Biol, 11, 557-68
Abstract
Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007) Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev, 21, 1478-83
Abstract