Prof. Dr. med. Robert Grosse
Qualifications and history
| 1998 | MD, Free University Berlin, Benjamin Franklin Campus |
| 1994-99 | Doctoral thesis, Institute of Pharmacology, Free University Berlin |
| 2000 | Postdoctoral fellow (EMBO Fellow), London Research Institute (LRI), UK |
| 2004 | Emmy Noether Group leader, University of Heidelberg, Medical Faculty |
| 2009 | Habilitation and Medical Specialization (Facharzt) in Pharmacology, University of Heidelberg |
| 2009 | Full professor and chair, Institute of Pharmacology, University of Marburg, Medical Faculty |
| 2019 | Full professor and chair, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Medical Faculty |
Honors and Awards
| 2023 | Member of the German National Academy of Sciences Leopoldina |
| 2016 | HFSP (Human Frontiers Science Program) lead investigator of program grant |
| 2013 | Binder-Innovation Prize of the German Society of Cell Biology |
Selected Publications
Kamaras C, Frank D, Wang H, Drepper F, Huesgen PF, Grosse R (2025) Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage. EMBO J, 44, 6112-36
Abstract
Knerr J, Werner R, Schwan C, Wang H, Gebhardt P, Grötsch H, Caliebe A, Spielmann M, Holterhus PM, Grosse R*, Hornig NC* (2023) Formin-mediated nuclear actin at androgen receptors promotes transcription. Nature, 617, 616-22, *co corresponding authors
Abstract
Krippner S, Winkelmeier J, Knerr J, Brandt DT, Virant D, Schwan C, Endesfelder U, Grosse R (2020) Postmitotic expansion of cell nuclei requires nuclear actin filament bundling by α-actinin 4. EMBO Rep, 21, e50758, 1-11
Abstract
Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R (2019) GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun, 10, 5271, 1-9
Abstract
Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R (2017) A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nat Cell Biol, 19, 1389-99
Abstract
Hinojosa LS, Holst M, Baarlink C, Grosse R (2017) MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol, 216, 3087-95
Abstract
Grikscheit K, Frank T, Wang Y, Grosse R (2015) Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol, 209, 367-76
Abstract
Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R (2015) Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell, 4, 475-83
Abstract
Baarlink C, Wang H, Grosse R (2013) Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science, 340, 864-7. Featured by 2013: Signaling breakthroughs of the year
Abstract
Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin. Nat Cell Biol, 11, 557-68
Abstract
Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007) Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev, 21, 1478-83
Abstract