Prof. Dr. med. Dr. rer. nat. Klaus Aktories
| Curriculum Vitae |  |
| Office Address | Institute of Experimental and Clinical Pharmacology and Toxicology Albert-Ludwigs-Universität Freiburg Albertstr. 25, Otto-Krayer-Haus D-79104 Freiburg, Germany |
Education |
|
| 1967 | High school examination |
| 1969-1972 | Study of Pharmacy, University of Frankfurt |
| 1971-1977 | Study of Medicine, University of Frankfurt |
Dissertations |
|
| 1977 Dr. med. (MD) | Faculty of Medicine, University of Frankfurt (Mentor Prof. Dr. H.-D. Taubert) |
| 1981 Dr. rer. nat. (Ph. D.) | Faculty of Natural Sciences (Naturwissenschaftl. Gesamtfakultät), University of Heidelberg (Mentor Prof. Dr. G. Schulz) |
Habilitation |
|
| 1983 | Faculty of Theoretical Medicine, University of Heidelberg |
Professional Appointments |
|
| 1978-1984 Research Associate | Department of Pharmacology at the University of Heidelberg (Group of Prof. Dr. G. Schultz) |
| 1984-1985 Research Associate | Department of Psychiatry at the University of Mainz (Director Prof. Dr. O. Benkert) |
| 1985-1989 Associate Professor (C2) | Rudolf-Buchheim-Institute of Pharmacology at the University of Gießen |
| 1989-1991 Associate Professor (C3) | Institute of Pharmacology at the University of Essen |
| 1991-1994 Full Professor (C4) | Institute of Pharmacology and Toxicology at the University of the Saarland |
| 1995-2018 Full Professor (C4) and Director (Chair) | Department I of the Institute of Experimental and Clinical Pharmacology and Toxicology at the Albert-Ludwigs-Universität Freiburg |
Sabbaticals |
|
| 1989 | Institute of Cancer Research, Chester Beatty Laboratories, London, Group of Prof. Dr. A. Hall |
| 1998 | Department of Microbiology and Molecular Genetics, Medical College Wisconsin (Milwaukee), Group of Prof. Dr. J.T. Barbieri |
Honors |
|
| Julius Friedrich Cohnheim Lecture, Tel Aviv University (1998) | |
| Member of The German Academy of Natural Scientists Leopoldina (2003) | |
| Coordinator of the Priority Research Program 1150 (Schwerpunktprogramm 1150) of the DFG: “Signalwege zum Zytoskelett und bakterielle | |
| Pathogenität” (2003-2009) | |
| Feldberg-Foundation Award (2005) | |
| Fellow of The American Academy of Microbiology (2008) | |
| Member of EMBO (2008) | |
| Phoenix Research Award (2012) | |
| Toxicology Award der Deutschen Gesellschaft für Toxikologie (2014) | |
| Senior Fellowship Freiburg Institute for Advanced Studies (FRIAS) (2015) | |
Membership in Editorial Boards (past and present) |
|
| European Journal of Pharmacology | |
| Naunyn-Schmiedeberg’s Archives of Pharmacology | |
| Medical Microbiology and Immunology | |
| Toxicon | |
| Infection and Immunity | |
| International Journal of Medical Microbiology | |
Research topics |
|
| Bacterial protein toxin - Clostridial glucosylating toxins - Pasteurella multocida toxin - ADP-ribosylating toxins - Rho-GTPase activating and inhibiting toxins - Legionella glucosyltransferases - ABC (Tc)-Toxins |
|
| Molecular mechanism and structure-function analysis of bacterial protein toxins | |
| Bacterial protein toxins as pharmacological tools | |
Patents |
|
| De0019802569A1 | Toxikologisch aktive Fragmente des letalen Toxins von Clostridium sordellii und deren Verwendung in Immuntoxinen |
| DE0019735105A1 | Transportsystem zur Einbringung von Proteinen in Zielzellen mit Hilfe eines Fusionsproteins, Nucleinsäurekonstrukte kodierend für die Komponenten des Transportsystems und Arzneimittel, die Komponenten des Transportsystems umfassen |
| EP1452589A1 | ADP-Ribosyltransferase C3cer |
Publications
2024 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Papatheodorou P, Minton NP, Aktories K, Barth H (2024) An Updated View on the Cellular Uptake and Mode-of-Action of Clostridioides difficile Toxins. Adv Exp Med Biol, 1435, 219-47
Abstract
Schneider S, Wirth C, Jank T, Hunte C, Aktories K (2024) Tyrosine-modifying glycosylation by Yersinia effectors. J Biol Chem, 107331, Epub ahead of print
Abstract
2023 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Aktories K (2023) Clostridioides difficile infection drives neuronal inflammation. Nature, 622, 465-7
Abstract
Aktories K (2023) From signal transduction to protein toxins-a narrative review about milestones on the research route of C. difficile toxins. Naunyn Schmiedebergs Arch Pharmacol, 396, 173-90
Abstract
Behren S, Schorlemer M, Schmidt G, Aktories K, Westerlind U (2023) Antibodies Directed Against GalNAc- and GlcNAc-O-Tyrosine Posttranslational Modifications - a New Tool for Glycoproteomic Detection. Chemistry, e202300392, Epub ahead of print
Abstract
2022 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Aktories K (2022) Another surprise in receptor binding of C. difficile toxins. Innovation (Camb), 3, 100261, 1-2
Abstract
Aktories K (2022) Treatment of ovarian cancer with modified anthrax toxin. Proc Natl Acad Sci U S A, 119 (32), e2210179119, 1-3
Abstract
Schwan C, Lang AE, Schlosser A, Fujita-Becker S, AlHaj A, Schröder RR, Faix J, Aktories K, Mannherz HG (2022) Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins. Cells, 11, 3661, 1-21
Abstract
Zähringer S, Rumpf T, Melesina J, Lang AE, Aktories K, Sippl W, Jung M, Wagner GK (2022) Defined stereoisomers of 2"-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase. Bioorg Med Chem, 68, 116875, 1-11
Abstract
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Ng'ang'a PN, Siukstaite L, Lang AE, Bakker H, Römer W, Aktories K, Schmidt G (2021) Involvement of N-glycans in binding of Photorhabdus luminescens Tc toxin. Cell Microbiol, 23, e13326, 1-16
Abstract
Papatheodorou P, Kindig S, Badilla-Lobo A, Fischer S, Durgun E, Thuraisingam T, Witte A, Song S, Aktories K, Chaves-Olarte E, Rodríguez C, Barth H (2021) The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB. Front Microbiol, 12, 784856, 1-10
Abstract
2020 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Antoni C, Quentin D, Lang AE, Aktories K, Gatsogiannis C, Raunser S (2020) Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. PLoS Pathog, 16, e1008530, 1-19
Abstract
Fischer S, Ückert AK, Landenberger M, Papatheodorou P, Hoffmann-Richter C, Mittler AK, Ziener U, Hägele M, Schwan C, Müller M, Kleger A, Benz R, Popoff MR, Aktories K, Barth H (2020) Human Peptide α-defensin-1 Interferes With Clostridioides Difficile Toxins TcdA, TcdB, and CDT. FASEB J, 34, 6244-61
Abstract
Korbmacher M, Fischer S, Landenberger M, Papatheodorou P, Aktories K, Barth H (2020) Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT. Front Pharmacol, 11, 1204, 1-10
Abstract
Ost GS, Wirth C, Bogdanović X, Kao WC, Schorch B, Aktories PJK, Papatheodorou P, Schwan C, Schlosser A, Jank T, Hunte C, Aktories K (2020) Inverse Control of Rab Proteins by Yersinia ADP-ribosyltransferase and Glycosyltransferase Related to Clostridial Glucosylating Toxins. Sci Adv, 6, eaaz2094, 1-12
Abstract
Simpson M, Frisbee A, Kumar P, Schwan C, Aktories K, Petri WA (2020) Clostridioides difficile binary toxin (CDT) is recognized by the TLR2/6 heterodimer to induce an NF-κB response. J Infect Dis, 225, 1296-300
Abstract
Reviews, Books
Aktories K (2020) Semaphorins or Frizzled -it is the receptor that direct the action of clostridial glucosylating toxins. Signal Transduct Target Ther, 5, 206, 1-2
Abstract
2019 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Bogdanovic X, Schneider S, Levanova N, Wirth C, Trillhaase C, Steinemann M, Hunte C, Aktories K, Jank T (2019) A cysteine protease-like domain enhances the cytotoxic effects of the Photorhabdus asymbiotica toxin PaTox. J Biol Chem, 294, 1035-44
Abstract
Ebner JK, König GM, Kostenis E, Siegert P, Aktories K, Orth JH (2019) Activation of Gq signaling by Pasteurella multocida toxin inhibits the osteoblastogenic-like actions of Activin A in C2C12 myoblasts, a cell model of fibrodysplasia ossificans progressiva. Bone, 127, 592-601
Abstract
Levanova N, Mattheis C, Carson D, To KN, Jank T, Frankel G, Aktories K, Schroeder GN (2019) The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase. J Biol Chem, 294, 2862-79
Abstract
Levanova N, Steinemann M, Böhmer KE, Schneider S, Belyi Y, Schlosser A, Aktories K, Jank T (2019) Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA. Naunyn Schmiedebergs Arch Pharmacol, 392, 69-79
Abstract
Ng Ang A PN, Ebner JK, Plessner M, Aktories K, Schmidt G (2019) Engineering Photorhabdus luminescens toxin complex (PTC) into a recombinant injection nanomachine. Life Sci Alliance, 2, e20190048, 1-12
Abstract
Ost GS, Ng'ang'a PN, Lang A, Aktories K (2019) Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells. Cell Microbiol, 21, e12978, 1-12
Abstract
Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K (2019) Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway. FASEB J, 33, 4883-92
Abstract
Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H (2019) Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication. FASEB J, 33, 5755-71
Abstract
Reviews, Books
Aktories K, Gierschik P, Heringdorf DMZ, Schmidt M, Schultz G, Wieland T (2019) cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs. Naunyn Schmiedebergs Arch Pharmacol, 392, 887-911
Abstract
2018 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC (2018) Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins. PLoS Pathog, 14, e1007248, 1-23
Abstract
Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, Aktories K, Borner C (2018) Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nat Commun, 9, 3524, 1-14
Abstract
Heni H, Ebner JK, Schmidt G, Aktories K, Orth JHC (2018) Involvement of Osteocytes in the Action of Pasteurella multocida Toxin. Toxins (Basel), 10, 328, 1-15
Abstract
Schorch B, Heni H, Zahaf NI, Brummer T, Mione M, Schmidt G, Papatheodorou P, Aktories K (2018) Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL. Oncotarget, 9, 16489-500
Abstract
Steinemann M, Schlosser A, Jank T, Aktories K (2018) The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A, 115, 9580-5
Abstract
Reviews, Books
Aktories K, Papatheodorou P, Schwan C (2018) Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton. Anaerobe, 53, 21-9
Abstract
Papatheodorou P, Barth H, Minton N, Aktories K (2018) Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins. Adv Exp Med Biol, 1050, 77-96
Abstract
2017 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Carle S, Brink T, Orth JH, Aktories K, Barth H (2017) Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication. Toxins (Basel), 9, 32, 1-8
Abstract
Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P (2017) Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells. Oncotarget, 8, 37009-22
Abstract
Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H (2017) Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells. Sci Rep, 7, 2724, 1-16
Abstract
Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K (2017) Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. J Biol Chem, 292, 16014-23
Abstract
Lang AE, Qu Z, Schwan C, Silvan U, Unger A, Schoenenberger CA, Aktories K, Mannherz HG (2017) Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin. Cell Microbiol, 19, 1-14
Abstract
Lang S, Busch H, Boerries M, Brummer T, Timme S, Lassmann S, Aktories K, Schmidt G (2017) Specific role of RhoC in tumor invasion and metastasis. Oncotarget, 8, 87364-78
Abstract
Østevold K, Meléndez AV, Lehmann F, Schmidt G, Aktories K, Schwan C (2017) Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells. Oncotarget, 8, 76686-98
Abstract
Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H (2017) The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep, 7, 613, 1-14
Abstract
Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G (2017) Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep, 7, 41252, 1-10
Abstract
Reviews, Books
Aktories K, Schwan C, Lang AE (2017) ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. Handb Exp Pharmacol, 235, 179-206
Abstract
Aktories K, Schwan C, Jank T (2017) Clostridium difficile Toxin Biology. Annu Rev Microbiol, 71, 281-307
Abstract
Papatheodorou P, Aktories K (2017) Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins. Curr Top Microbiol Immunol, 406, 119-33
Abstract
Schwan C, Aktories K (2017) Formation of Nanotube-Like Protrusions, Regulation of Septin Organization and Re-guidance of Vesicle Traffic by Depolymerization of the Actin Cytoskeleton Induced by Binary Bacterial Protein Toxins. Curr Top Microbiol Immunol, 399, 35-51
Abstract
Sheets J, Aktories K (2017) Insecticidal Toxin Complexes from Photorhabdus luminescens. Curr Top Microbiol Immunol, 402, 3-23
Abstract
2016 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr (2016) The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia. Nat Microbiol, 1, 16108
Abstract
Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K (2016) Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proc Natl Acad Sci U.S.A, 113, 7870-5
Abstract
Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Tehran DA, Montecucco C, Barth H (2016) EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin. Toxins (Basel), 8, 101, 1-14
Abstract
Reviews, Books
Jank T, Lang AE, Aktories K (2016) Rho-modifying bacterial protein toxins from Photorhabdus species. Toxicon, 116, 17-22
Abstract
Papatheodorou P, Aktories K (2016) Preface for Anaerobe - Special issue on Clostpath9. Anaerobe, 41, 1
Abstract
2015 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Belyy A, Tabakova I, Lang AE, Jank T, Belyi Y, Aktories K (2015) Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin. PLoS One, 10, e0145708, 1-15
Abstract
Ernst K, Langer S, Kaiser E, Osseforth C, Michaelis J, Popoff MR, Schwan C, Aktories K, Kahlert V, Malesevic M, Schiene-Fischer C, Barth H (2015) Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins. J Mol Biol, 427, 1224-38
Abstract
Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P (2015) Interaction of the Clostridium difficile Binary Toxin CDT and its Host Cell Receptor LSR. J Biol Chem, 290, 14031-44
Abstract
Jank T, Eckerle S, Steinemann M, Trillhaase C, Schimpl M, Wiese S, van Aalten DM, Driever W, Aktories K (2015) Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos. Nat Commun, 6, 7807, 1-16
Abstract
Jank T, Trillhaase C, Brozda N, Steinemann M, Schwan C, Süss R, Aktories K (2015) Intracellular plasma membrane guidance of Photorhabdus asymbiotica toxin is crucial for cell toxicity. FASEB J, 29, 2789-802
Abstract
Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L (2015) Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res, 117, 622-33
Abstract
Pfaumann V, Lang AE, Schwan C, Schmidt G, Aktories K (2015) The actin and Rho-modifying toxins PTC3 and PTC5 of Photorhabdus luminescens: Enzyme characterization and induction of MAL/SRF-dependent transcription. Cell Microbiol, 17, 579-94
Abstract
Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA (2015) Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem, 290, 9363-76
Abstract
Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F (2015) Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT. Sci Rep, 5, 7850, 1-10
Abstract
Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JH (2015) A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice. Cell Microbiol, 17, 1320-31
Abstract
Reviews, Books
Aktories K, Schmidt G, Lang AE (2015) Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine. Curr Top Microbiol Immunol, 384, 53-67
Abstract
Aktories K (2015) Rho-modifying bacterial protein toxins. Pathog Dis, 73, ftv091, 1-10
Abstract
Jank T, Belyi Y, Aktories K (2015) Bacterial glycosyltransferase toxins. Cell Microbiol, 17, 1752-65
Abstract
Schmidt G, Papatheodorou P, Aktories K (2015) Novel receptors for bacterial protein toxins. Curr Opin Microbiol, 23, 55-61
Abstract
2014 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K (2014) The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases. Cell Microbiol, 16, 490-503
Abstract
Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O, Vetter IR, Aktories K, Raunser S (2014) Mechanism of Tc toxin action revealed in molecular detail. Nature, 508, 61-5
Abstract
Piteau M, Papatheodorou P, Schwan C, Schlosser A, Aktories K, Schmidt G (2014) Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1). PLoS Pathog, 10, e1003884, 1-12
Abstract
Roeder M, Nestorovich EM, Karginov VA, Schwan C, Aktories K, Barth H (2014) Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT. Toxins (Basel), 6, 2097-114
Abstract
Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K (2014) LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci U.S.A, 111, 6431-6
Abstract
Schwan C, Kruppke AS, Nölke T, Schumacher L, Koch-Nolte F, Kudryashev M, Stahlberg H, Aktories K (2014) Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence. Proc Natl Acad Sci U.S.A, 111, 2313-8
Abstract
Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JH (2014) Noncanonical G-Protein-Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin. MBio, 5, e02190-14, 1-9
Abstract
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G (2014) The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation. Nat Commun, 5, 5887, 1-10
Abstract
Reviews, Books
Aktories K, Schmidt G (2014) Bacterial Protein Toxins Acting on Small GTPases. In: Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Wittinghofer, A (ed.), Springer Vienna, 64-97
Abstract
Gerding DN, Johnson S, Rupnik M, Aktories K (2014) Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance. Gut Microbes, 5, 15-27
Abstract
Simon NC, Aktories K, Barbieri JT (2014) Novel bacterial ADP-ribosylating toxins: structure and function. Nat Rev Microbiol, 12, 599-611
Abstract
2013 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Augspach A, List JH, Wolf P, Bielek H, Schwan C, Elsässer-Beile U, Aktories K, Schmidt G (2013) Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells. Toxins (Basel), 5, 2241-57
Abstract
Bergmann S, Jehle D, Schwan C, Orth JH, Aktories K (2013) Pasteurella multocida Toxin as a Transporter of Non-Cell-Permeating Proteins. Infect Immun, 81, 2459-67
Abstract
Gatsogiannis C, Lang AE, Meusch D, Pfaumann V, Hofnagel O, Benz R, Aktories K, Raunser S (2013) A syringe-like injection mechanism in Photorhabdus luminescens toxins. Nature, 495, 520-3
Abstract
Jank T, Bogdanović X, Wirth C, Haaf E, Spoerner M, Böhmer KE, Steinemann M, Orth JH, Kalbitzer HR, Warscheid B, Hunte C, Aktories K (2013) A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nat Struct Mol Biol, 20, 1273-80
Abstract
Lang AE, Konukiewitz J, Aktories K, Benz R (2013) TcdA1 of Photorhabdus luminescens: electrophysiological analysis of pore formation and effector binding. Biophys J, 105, 376-84
Abstract
Orth JH, Fester I, Siegert P, Weise M, Lanner U, Kamitani S, Tachibana T, Wilson BA, Schlosser A, Horiguchi Y, Aktories K (2013) Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins. FASEB J, 27, 832-42
Abstract
Papatheodorou P, Hornuss D, Nölke T, Hemmasi S, Castonguay J, Picchianti M, Aktories K (2013) Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts. MBio, 4, e00244-13, 1-8
Abstract
Sakaba T, Kononenko NL, Bacetic J, Pechstein A, Schmoranzer J, Yao L, Barth H, Shupliakov O, Kobler O, Aktories K, Haucke V (2013) Fast neurotransmitter release regulated by the endocytic scaffold intersectin. Proc Natl Acad Sci U.S.A, 110, 8266-71
Abstract
Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth JH (2013) Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gαq/11-p63RhoGEF-RhoA axis. PLoS Pathog, 9, e1003385, 1-14
Abstract
Singh MK, Ren F, Giesemann T, Bosco CD, Pasternak TP, Blein T, Ruperti B, Schmidt G, Aktories K, Molendijk AJ, Palme K (2013) Modification of plant Rac/Rop GTPase signalling using bacterial toxin transgenes. Plant J, 73, 314–24
Abstract
Reviews, Books
Belyi Y, Jank T, Aktories K (2013) Cytotoxic Glucosyltransferases of Legionella pneumophila. Curr Top Microbiol Immunol, 376, 211-26
Abstract
Jank T, Aktories K (2013) Strain-alleviation model of ADP-ribosylation. Proc Natl Acad Sci U.S.A, 110, 4163-4
Abstract
Lemichez E, Aktories K (2013) Hijacking of Rho GTPases during bacterial infection. Exp Cell Res, 319, 2329-36
Abstract
2012 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Belyi Y, Tartakovskaya D, Tais A, Fitzke E, Tzivelekidis T, Jank T, Rospert S, Aktories K (2012) Elongation Factor 1A Is the Target of Growth Inhibition in Yeast Caused by Legionella pneumophila Glucosyltransferase Lgt1. J Biol Chem, 287, 26029-37
Abstract
Guttenberg G, Hornei S, Jank T, Schwan C, Lü W, Einsle O, Papatheodorou P, Aktories K (2012) Molecular Characteristics of Clostridium perfringens TpeL Toxin and Consequences of Mono-O-GlcNAcylation of Ras in Living Cells. J Biol Chem, 287, 24929-40
Abstract
Jank T, Böhmer KE, Tzivelekidis T, Schwan C, Belyi Y, Aktories K (2012) Domain organization of Legionella effector SetA. Cell Microbiol, 14, 852-68
Abstract
Kaiser E, Böhm N, Ernst K, Langer S, Schwan C, Aktories K, Popoff M, Fischer G, Barth H (2012) FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells. Cell Microbiol, 14, 1193-205
Abstract
Papatheodorou P, Wilczek C, Nölke T, Guttenberg G, Hornuss D, Schwan C, Aktories K (2012) Identification of the cellular receptor of Clostridium spiroforme toxin. Infect Immun, 80, 1418-23
Abstract
Reipschläger S, Kubatzky K, Taromi S, Burger M, Orth J, Aktories K, Schmidt G (2012) Toxin-induced RhoA activity mediates CCL1-triggered signal transducers and activators of transcription protein signaling. J Biol Chem, 287, 11183-94
Abstract
Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA (2012) Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by the inhibition of Rac GTPase activity. J Biol Chem, 287, 16835-48
Abstract
Reviews, Books
Aktories K, Schwan C, Papatheodorou P, Lang AE (2012) Bidirectional attack on the actin cytoskeleton. Bacterial protein toxins causing polymerization or depolymerization of actin. Toxicon, 60, 572-81
Abstract
Orth JH, Aktories K (2012) Molecular Biology of Pasteurella multocida Toxin. Curr Top Microbiol Immunol, 361, 73-92
Abstract
2011 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Dmochewitz L, Lillich M, Kaiser E, Jennings LD, Lang AE, Buchner J, Fischer G, Aktories K, Collier RJ, Barth H (2011) Role of CypA and Hsp90 in membrane translocation mediated by anthrax Protective Antigen. Cell Microbiol, 13, 359-73
Abstract
Genisyuerek S, Papatheodorou P, Guttenberg G, Schubert R, Benz R, Aktories K (2011) Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B. Mol Microbiol, 79, 1643-54
Abstract
Guttenberg G, Papatheodorou P, Genisyuerek S, Lü W, Jank T, Einsle O, Aktories K (2011) Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin. J Biol Chem, 286, 14779-86
Abstract
Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C (2011) RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell, 22, 593-605
Abstract
Kaiser E, Kroll C, Ernst K, Schwan C, Popoff M, Fischer G, Buchner J, Aktories K, Barth H (2011) Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by Cyclophilin A and Hsp90. Infect Immun, 79, 3913-21
Abstract
Maurer B, Mathias U, Papatheodorou P, Shekfeh S, Orth J, Jank T, Schwan C, Sippl W, Aktories K, Jung M (2011) From cosubstrate similarity to inhibitor diversity-inhibitors of ADP-ribosyltransferases from kinase inhibitor screening. Mol Biosyst, 7, 799-808
Abstract
Orth JH, Schorch B, Boundy S, Ffrench-Constant R, Kubick S, Aktories K (2011) Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae. Toxicon, 57, 199-207
Abstract
Papatheodorou P, Carette JE, Bell GW, Schwan C, Guttenberg G, Brummelkamp TR, Aktories K (2011) Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT). Proc Natl Acad Sci U.S.A, 108, 16422-7
Abstract
Schwan C, Nöelke T, Kruppke AS, Schubert DM, Lang AE, Aktories K (2011) Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by clostridium difficile transferase CDT. J Biol Chem, 286, 29356-65
Abstract
Sheets JJ, Hey TD, Fencil KJ, Burton SL, Ni W, Lang AE, Benz R, Aktories K (2011) Insecticidal toxin complex proteins from Xenorhabdus nematophilus: Structure and pore formation. J Biol Chem, 286, 22742-9
Abstract
Tzivelekidis T, Jank T, Pohl C, Schlosser A, Rospert S, Knudsen CR, Rodnina MV, Belyi Y, Aktories K (2011) Aminoacyl-tRNA-Charged Eukaryotic Elongation Factor 1A Is the Bona Fide Substrate for Legionella pneumophila Effector Glucosyltransferases. PLoS One, 6, e29525, 1-11
Abstract
Reviews, Books
Aktories K (2011) Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol, 9, 487-98
Abstract
Aktories K, Lang AE, Schwan C, Mannherz HG (2011) Actin as target for modification by bacterial protein toxins. FEBS J, 278, 4526-43
Abstract
Barth H, Aktories K (2011) New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin. Eur J Cell Biol, 90, 944-50
Abstract
Belyi Y, Jank T, Aktories K (2011) Effector glycosyltransferases in legionella. Front Microbiol, 2, 1-11
Abstract
Lang AE, Schmidt G, Sheets JJ, Aktories K (2011) Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens. Naunyn Schmiedebergs Arch Pharmacol, 383, 227-35
Abstract
Schmidt G, Aktories K (2011) The priority program Signal Pathways to the Cytoskeleton and Bacterial Pathogenesis (SPP1150). Eur J Cell Biol, 90, 879
Abstract
2010 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Gündogdu MS, Liu H, Metzdorf D, Hildebrand D, Aigner M, Aktories K, Heeg K, Kubatzky KF (2010) The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression. Mol Cancer, 9, 225
Abstract
Lang AE, Schmidt G, Schlosser A, Hey TD, Larrinua IM, Sheets JJ, Mannherz HG, Aktories K (2010) Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. Science, 327, 1139-42
Abstract
Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O (2010) Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila. J Mol Biol, 396, 321-31
Abstract
Papatheodorou P, Zamboglou C, Genisyuerek S, Guttenberg G, Aktories K (2010) Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis. PLoS One, 5, e10673, 1-8
Abstract
Preuß I, Hildebrand D, Orth JH, Aktories K, Kubatzky KF (2010) Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cell Microbiol, 12, 1174-85
Abstract
Sterthoff C, Lang AE, Schwan C, Tauch A, Aktories K (2010) Functional characterization of an extended binding component of the actin-ADP-ribosylating C2 toxin detected in Clostridium botulinum strain (C) 2300. Infect Immun, 78, 1468-74
Abstract
Stratmann H, Schwan C, Orth JH, Schmidt G, Aktories K (2010) Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin. Cell Signal, 22, 1124-31
Abstract
Reviews, Books
Belyi Y, Aktories K (2010) Bacterial toxin and effector glycosyltransferases. Biochim Biophys Acta, 1800, 134-43
Abstract
Orth JH, Aktories K (2010) Pasteurella multocida Toxin Activates Various Heterotrimeric G Proteins by Deamidation. Toxins, 2, 205-14
Abstract
2009 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Belyi Y, Stahl M, Sovkova I, Kaden P, Luy B, Aktories K (2009) Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase LGT1-identification of LGT1 as a retaining glucosyltransferase. J Biol Chem, 284, 20167-74
Abstract
Egerer M, Giesemann T, Herrmann C, Aktories K (2009) Autocatalytic processing of Clostridium difficile toxin B: Binding of inositol hexakisphosphate. J Biol Chem, 284, 3389-95
Abstract
Knust Z, Blumenthal B, Aktories K, Schmidt G (2009) Cleavage of Escherichia coli cytotoxic necrotizing factor 1 is required for full biologic activity. Infect Immun, 77, 1835-41
Abstract
Orth JH, Preuß I, Fester I, Schlosser A, Wilson BA, Aktories K (2009) Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation. Proc Natl Acad Sci U.S.A, 106, 7179-84
Abstract
Preuß I, Kurig B, Nürnberg B, Orth JH, Aktories K (2009) Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins. Cell Signal, 21, 551-8
Abstract
Schwan C, Stecher B, Tzivelekidis T, van Ham M, Rohde M, Hardt WD, Wehland J, Aktories K (2009) Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog, 5, e1000626, 1-14
Abstract
Reviews, Books
Orth JH, Aktories K (2009) Activation of heterotrimeric G proteins by Pasteurella multocida toxin. Toxins and signalling, SFET, RT17, 45-50
E-Book RT
Orth JH, Schmidt G, Aktories K (2009) Bakterielle Toxine aktivieren GTPasen durch Deamidierung. Toxine und Signaling, BIOSpektrum, 5/2009, 501-3
5/2009
2008 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Belyi Y, Tabakova I, Stahl M, Aktories K (2008) Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila. J. Bacteriol, 190, 3026-35
Abstract
Büch TR, Biebermann H, Kalwa H, Pinkenburg O, Hager D, Barth H, Aktories K, Breit A, Gudermann T (2008) G13-dependent Activation of MAPK by Thyrotropin. J Biol Chem, 283, 20330-41
Abstract
Giesemann T, Guttenberg G, Aktories K (2008) Human α-defensins inhibit Clostridium difficile toxin B. Gastroenterology, 134, 2049-58
Abstract
Hennig B, Orth J, Aktories K, Diener M (2008) Anion secretion evoked by Pasteurella multocida toxin across rat colon. Eur J Pharmacol, 583, 156-63
Abstract
Jank T, Ziegler MO, Schulz GE, Aktories K (2008) Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine. FEBS Lett, 582, 2277-82
Abstract
Lang AE, Neumeyer T, Sun J, Collier RJ, Benz R, Aktories K (2008) Amino Acid Residues Involved in Membrane Insertion and Pore Formation of Clostridium botulinum C2 Toxin. Biochemistry, 47, 8406-13
Abstract
Neumeyer T, Schiffler B, Maier E, Lang AE, Aktories K, Benz R (2008) Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel. J Biol Chem, 283, 3904-14
Abstract
Orth JH, Fester I, Preuß I, Agnoletto L, Wilson BA, Aktories K (2008) Activation of Gαi and subsequent uncoupling of receptor-Gαi signaling by Pasteurella multocida toxin. J Biol Chem, 283, 23288-94
Abstract
Sun J, Lang AE, Aktories K, Collier RJ (2008) Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U.S.A, 105, 4346-51
Abstract
Treiber N, Reinert DJ, Carpusca I, Aktories K, Schulz GE (2008) Structure and mode of action of a mosquitocidal holotoxin. J Mol Biol, 381, 150-9
Abstract
Vogelsgesang M, Stieglitz B, Herrmann C, Pautsch A, Aktories K (2008) Crystal structure of the Clostridium limosum C3 exoenzyme. FEBS Lett, 582, 1032-6
Abstract
Ziegler MO, Jank T, Aktories K, Schulz GE (2008) Conformational changes and reaction of clostridial glycosylating toxins. J Mol Biol, 377, 1346-56
Abstract
Reviews, Books
Giesemann T, Aktories K (2008) Glucosylierende Toxine von Clostridium difficile. Hygiene Medizin, 33, 374-8.
Giesemann T, Egerer M, Jank T, Aktories K (2008) Processing of Clostridium difficile toxins. J Med Microbiol, 57, 690-6
Abstract
Jank T, Aktories K (2008) Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol, 16, 222-9
Abstract
2007 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Blumenthal B, Hoffmann C, Aktories K, Backert S, Schmidt G (2007) The Cytotoxic Necrotizing Factors from Yersinia pseudotuberculosis (CNFY) and from Escherichia coli (CNF1) Bind to Different Cellular Receptors but Take the Same Route to the Cytosol. Infect Immun, 75, 3344-53
Abstract
Egerer M, Giesemann T, Jank T, Satchell KJ, Aktories K (2007) Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on a cysteine protease activity. J Biol Chem, 282, 25314-21
Abstract
Hoffmann C, Aktories K, Schmidt G (2007) Change in Substrate Specificity of Cytotoxic Necrotizing Factor Unmasks Proteasome-independent Down-regulation of Constitutively Active RhoA. J Biol Chem, 282, 10826-32
Abstract
Jank T, Giesemann T, Aktories K (2007) Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding. J Biol Chem, 282, 35222-31
Abstract
Orth JH, Aktories K, Kubatzky KF (2007) Modulation of host cell gene expression through activation of stat transcription factors by pasteurella multocida toxin. J Biol Chem, 282, 3050-7
Abstract
Orth JH, Lang S, Preuß I, Milligan G, Aktories K (2007) Action of Pasteurella multocida toxin on Gαq is persistent and independent of interaction with G-protein-coupled receptors. Cell Signal, 19, 2174-82
Abstract
Pust S, Hochmann H, Kaiser E, von Figura G, Heine K, Aktories K, Barth H (2007) A Cell-permeable Fusion Toxin as a Tool to Study the Consequences of Actin-ADP-ribosylation Caused by the Salmonella enterica Virulence Factor SpvB in Intact Cells. J Biol Chem, 282, 10272-82
Abstract
Reviews, Books
Aktories K (2007) Self-cutting to kill: new insights into the processing of toxins. ACS Chem Biol, 2, 228-30
Abstract
Jank T, Giesemann T, Aktories K (2007) Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. Glycobiology, 17, 15R-22R
Abstract
Vogelsgesang M, Pautsch A, Aktories K (2007) C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins. Naunyn Schmiedebergs Arch Pharmacol, 374, 347-60
Abstract
2006 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Belyi Y, Niggeweg R, Opitz B, Vogelsgesang M, Hippenstiel S, Wilm M, Aktories K (2006) Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A. Proc Natl Acad Sci U S A, 103, 16953-8
Abstract
Blöcker D, Berod L, Fluhr JW, Orth J, Idzko M, Aktories K, Norgauer J (2006) Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis. Int Immunol, 18, 459-64
Abstract
Füller F, Bergo MO, Young SG, Aktories K, Schmidt G (2006) Endoproteolytic Processing of RhoA by Rce1 Is Required for the Cleavage of RhoA by Yersinia enterocolitica Outer Protein T. Infect Immun, 74, 1712-7
Abstract
Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K (2006) Cholesterol-dependent pore formation of clostridium difficile toxin A. J Biol Chem, 28, 10808-15
Abstract
Hochmann H, Pust S, von Figura G, Aktories K, Barth H (2006) Salmonella enterica SpvB ADP-Ribosylates Actin at Position Arginine-177-Characterization of the Catalytic Domain within the SpvB Protein and a Comparison to Binary Clostridial Actin-ADP-Ribosylating Toxins. Biochemistry, 45, 1271-7
Abstract
Jank T, Pack U, Giesemann T, Schmidt G, Aktories K (2006) Exchange of a single amino acid switches the substrate properties of RhoA and RhoD toward glucosylating and transglutaminating toxins. J Biol Chem, 281, 19527-35
Abstract
Kaiser E, Haug G, Hliscs M, Aktories K, Barth H (2006) Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction. Biochemistry, 45, 13361-8
Abstract
Lessmann E, Grochowy G, Weingarten L, Giesemann T, Aktories K, Leitges M, Krystal G, Huber M (2006) Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. Exp Hematol, 34, 1532-41
Abstract
Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, Linseman DA (2006) Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J Neurochem, 97, 957-67
Abstract
Majumder S, Schmidt G, Lohia A, Aktories K (2006) EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins. Appl Environ Microbiol, 72, 7842-8
Abstract
Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal GS (2006) Localization of the C3-Like ADP-ribosyltransferase from Staphylococcus aureus during bacterial invasion of mammalian cells. Infect Immun, 74, 3673-7
Abstract
Reinert DJ, Carpusca I, Aktories K, Schulz GE (2006) Structure of the Mosquitocidal Toxin from Bacillus sphaericus. J Mol Biol, 357, 1226-36
Abstract
Schleberger C, Hochmann H, Barth H, Aktories K, Schulz GE (2006) Structure and Action of the Binary C2 Toxin from Clostridium botulinum. J Mol Biol, 364, 705-15
Abstract
Vogelsgesang M, Aktories K (2006) Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme. Biochemistry, 45, 1017-25
Abstract
Reviews, Books
Aktories K (2006) Toxins as Tools. In: The Comprehensive Sourcebook of Bacterial Protein Toxins (Third Edition). Joseph E. Alouf and Michel R. Popoff (eds.), Elsevier Ltd, 976-90
Abstract
Carpusca I, Jank T, Aktories K (2006) Bacillus sphaericus mosquitocidal toxin (MTX) and pierisin: the enigmatic offspring from the family of ADP-ribosyltransferases. Mol Microbiol, 62, 621-30
Abstract
Haug G, Barth H, Aktories K (2006) Purification and activity of the Rho ADP-ribosylating binary C2/C3 toxin. Methods Enzymol, 406, 117-27
Abstract
2005 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Fortemaison N, Blancquaert S, Dumont JE, Maenhaut C, Aktories K, Roger PP, Dremier S (2005) Differential involvement of the actin cytoskeleton in differentiation and itogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis. Endocrinology, 146, 5485-95
Abstract
Jank T, Reinert DJ, Giesemann T, Schulz GE, Aktories K (2005) Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis. J Biol Chem, 280, 37833-8
Abstract
Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA (2005) Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem, 94, 1025-39
Abstract
Orth JH, Lang S, Taniguchi M, Aktories K (2005) Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of Ga proteins, Gaq and Ga12/13. J Biol Chem, 280, 36701-7
Abstract
Pautsch A, Vogelsgesang M, Trankle J, Herrmann C, Aktories K (2005) Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. EMBO J, 24, 3670-80
Abstract
Reinert DJ, Jank T, Aktories K, Schulz GE (2005) Structural basis for the function of Clostridium difficile toxin B. J Mol Biol, 351, 973-81
Abstract
Reviews, Books
Aktories K (2005) Bacterial Protein Toxins as Tools in Cell Biology and Pharmacology. In: Cellular Microbiology. Cossart P, Boquet P, Normark S, Rappuoli R (eds.), ASM Press Washington, DC, second edition, 341-60.
Aktories K, Barbieri JT (2005) Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol, 3, 397-410
Abstract
Aktories K, Just I (2005) Clostridial Rho-inhibiting protein toxins. Curr Top Microbiol Immunol, 291, 113-45
Abstract
Barth H, Aktories K (2005) Clostridial cytotoxins. In: Handbook on Clostridia. Dürre P (ed.), Taylor & Francis Group, Boca Raton, 407-49
Schmidt G, Aktories K (2005) Rho-activating toxins and growth regulation. In: Bacterial Protein Toxins. Role in the Interference with Cell Growth Regulation. Lax AJ (ed.), Advances in Molecular and Cellular Microbiology 7, Cambridge University Press, 33-52.
2004 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Averbeck M, Braun T, Pfeifer G, Sleeman J, Dudda J, Martin SF, Kremer B, Aktories K, Simon JC, Termeer C (2004) Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells. Eur J Immunol, 34, 2708-19
Abstract
Carpusca I, Schirmer J, Aktories K (2004) Two-site autoinhibition of the ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus by its 70-kDa ricin-like binding domain. Biochemistry, 43, 12009-19
Abstract
Haug G, Aktories K, Barth H (2004) The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins. Infect Immun, 72, 3066-8
Abstract
Hoffmann C, Pop M, Leemhuis J, Schirmer J, Aktories K, Schmidt G (2004) The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA. J Biol Chem, 279, 16026-32
Abstract
Leemhuis J, Boutillier S, Barth H, Feuerstein TJ, Brock C, Nurnberg B, Aktories K, Meyer DK (2004) Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites. J Biol Chem, 279, 585-96
Abstract
Orth JH, Lang S, Aktories K (2004) Action of Pasteurella multocida toxin depends on the helical domain of Gαq. J Biol Chem, 279, 34150-5
Abstract
Pop M, Aktories K, Schmidt G (2004) Isotype-specific Degradation of Rac Activated by the Cytotoxic Necrotizing Factor 1. J Biol Chem, 279, 35840-8
Abstract
Reviews, Books
Aktories K (2004) Bakterielle Toxine. In: Allgemeine und spezielle Pharmakologie und Toxikologie. Aktories, Förstermann, Hofmann, Starke (Hrsg.), Elsevier Urban & Fischer, 9. Auflage, 1089-103.
Aktories K, Barth H (2004) Clostridium botulinum C2 toxin - new insights into the cellular up-take of the actin-ADP-ribosylating toxin. Int J Med Microbiol, 293, 557-64
Abstract
Aktories K, Barth H (2004) The actin-ADP-ribosylating Clostridium botulinum C2 toxin. Anaerobe, 10, 101-5
Abstract
Aktories K, und Unger C (2004) Mittel zur Behandlung von Tumoren – Tumorchemotherapie. In: Allgemeine und spezielle Pharmakologie und Toxikologie. Aktories, Förstermann, Hofmann, Starke (Hrsg.), Elsevier Urban & Fischer, 9. Auflage, 921-59.
Aktories K, Wilde C, Vogelsgesang M (2004) Rho-modifying C3-like ADP-ribosyltransferases. Rev Physiol Biochem Pharmacol, 152, 1-22
Abstract
Barth H, Aktories K, Popoff MR, Stiles BG (2004) Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev, 68, 373-402
Abstract
Schirmer J, Aktories K (2004) Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins. Biochim Biophys Acta, 1673, 66-74
Abstract
2003 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Bachmeyer C, Orlik F, Barth H, Aktories K, Benz R (2003) Mechanism of C2-toxin Inhibition by Fluphenazine and Related Compounds: Investigation of their Binding Kinetics to the C2II-channel using the Current Noise Analysis. J Mol Biol, 333, 527-40
Abstract
Blöcker D, Bachmeyer C, Benz R, Aktories K, Barth H (2003) Channel Formation by the Binding Component of Clostridium botulinum C2 Toxin: Glutamate 307 of C2II Affects Channel Properties in Vitro and pH-Dependent C2I Translocation in Vivo. Biochemistry, 42, 5368-77
Abstract
Blöcker D, Pohlmann K, Haug G, Bachmeyer C, Benz R, Aktories K, Barth H (2003) Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells. J Biol Chem, 278, 37360-7
Abstract
Djouder N, Aneiros E, Cavalié A, Aktories K (2003) Effects of large clostridial cytotoxins on activation of RBL 2H3-hm1 mast cells indicate common and different roles of Rac in FcεRI and M1-receptor signaling. J Pharmacol Exp Ther, 304, 1243-50
Abstract
Frisch C, Gerhard R, Aktories K, Hofmann F, Just I (2003) The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis. Biochem Biophys Res Commun, 300, 706-11
Abstract
Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just I (2003) Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex. J Biol Chem, 278, 28523-7
Abstract
Genth H, Schmidt M, Gerhard R, Aktories K, Just I (2003) Activation of phospholipase D1 by ADP-ribosylated RhoA. Biochem Biophys Res Commun, 302, 127-32
Abstract
Gerhard R, John H, Aktories K, Just I (2003) Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases. Mol Pharmacol, 63, 1349-55
Abstract
Geyer M, Wilde C, Selzer J, Aktories K, Kalbitzer HR (2003) Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy. Biochemistry, 42, 11951-9
Abstract
Haug G, Leemhuis J, Tiemann D, Meyer DK, Aktories K, Barth H (2003) The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol. J Biol Chem, 278, 32266-74
Abstract
Haug G, Wilde C, Leemhuis J, Meyer DK, Aktories K, Barth H (2003) Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain. Biochemistry, 42, 15284-91
Abstract
Orth JH Blöcker D, Aktories K (2003) His1205 and His1223 Are Essential for the Activity of the Mitogenic Pasteurella multocida Toxin. Biochemistry, 42, 4971-7
Abstract
Pfeifer G, Schirmer J, Leemhuis J, Busch C, Meyer DK, Aktories K, Barth H (2003) Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells. J Biol Chem, 278, 44535-41
Abstract
Sorg I, Hoffmann C, Dumbach J, Aktories K, Schmidt G (2003) The C terminus of YopT is crucial for activity and the N terminus is crucial for substrate binding. Infect Immun, 71, 4623-32
Abstract
Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne HR (2003) Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol, 160, 375-85
Abstract
Waschke J, Baumgartner W, Adamson RH, Zeng M, Aktories K, Barth H, Wilde C, Curry FE, Drenckhahn D (2003) Requirement of Rac Activity for Maintenance of Capillary Endothelial Barrier Properties. Am J Physiol Heart Circ Physiol, 286, 394-401
Abstract
Wilde C, Vogelsgesang M, Aktories K (2003) Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization. Infect Biochemistry, 42, 9694-702
Abstract
Reviews, Books
Aktories K, Schmidt G (2003) A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors. Trends Microbiol, 11, 152-5
Abstract
2002 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Adamson RH, Curry FE, Adamson G, Liu B, Jiang Y, Aktories K, Barth H, Daigeler A, Golenhofen N, Ness W, Drenckhahn D (2002) Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice. J Physiol, 539, 295-308
Abstract
Barth H, Roebling R, Fritz M, Aktories K (2002) The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components. J Biol Chem, 277, 5074-81
Abstract
Carton I, Trouet D, Hermans D, Barth H, Aktories K, Droogmans G, Jorgensen NK, Hoffmann EK, Nilius B, Eggermont J (2002) RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells. Am J Physiol Cell Physiol, 283, C115-25
Abstract
Kerkhoff E, Leberfinger CB, Schmidt G, Aktories K, Rapp UR (2002) Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control. Biochim Biophys Acta, 1589, 151-9
Abstract
Lerm M, Pop M, Fritz G, Aktories K, Schmidt G (2002) Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac. Infect Immun, 70, 4053-8
Abstract
Li X, Saint-Cyr-Proulx E, Aktories K, Lamarche-Vane N (2002) Rac1 and Cdc42 but not RhoA or Rho-kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J Biol Chem, 277, 15207-14
Abstract
Riese MJ, Goehring UM, Ehrmantraut ME, Moss J, Barbieri JT, Aktories K, Schmidt G (2002) Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. J Biol Chem, 277, 12082-8
Abstract
Schirmer J, Just I, Aktories K (2002) The ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus - proteolytic activation, enzyme activity and cytotoxic effects. J Biol Chem, 277, 11941-8
Abstract
Schirmer J, Wieden HJ, Rodnina MV, Aktories K (2002) Inactivation of the Elongation Factor Tu by Mosquitocidal Toxin-Catalyzed Mono-ADP-Ribosylation. Appl Environ Microbiol, 68, 4894-9
Abstract
Wilde C, Barth H, Sehr P, Han L, Schmidt M, Just I, Aktories K (2002) Interaction of the Rho-ADP-ribosylating C3 Exoenzyme with RalA. J Biol Chem, 277, 14771-6
Abstract
Wilde C, Just I, Aktories K (2002) Structure-function analysis of the Rho-ADP-ribosylating exoenzyme C3stau2 from Staphylococcus aureus. Biochemistry, 41, 1539-44
Abstract
Reviews, Books
Barth H, Blocker D, Aktories K (2002) The uptake machinery of clostridial actin ADP-ribosylating toxins - a cell delivery system for fusion proteins and polypeptide drugs. Naunyn Schmiedebergs Arch Pharmacol, 366, 501-12
Abstract
Barbieri JT, Riese MJ, Aktories K (2002) Bacterial toxins that modify the actin cytoskeleton. Annu Rev Cell Dev Biol, 18, 315-44
Abstract
Wilde C, Chhatwal GS, Aktories K (2002) C3stau, a new member of the family of C3-like ADP-ribosyltransferases. Trends Microbiol, 10, 5-7
Abstract
2001 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Bachmeyer C, Benz R, Barth H, Aktories K, Gilbert M, Popoff MR (2001) Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo. FASEB J, 15, 1658-60
Abstract
Ballweber E, Galla M, Aktories K, Yeoh S, Weeds AG, Mannherz HG (2001) Interaction of ADP-ribosylated actin with actin binding proteins. FEBS Lett, 508, 131-5
Abstract
Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K (2001) Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells. J Biol Chem, 276, 10670-6
Abstract
Blöcker D, Behlke J, Aktories K, Barth H (2001) Cellular uptake of the Clostridium perfringens binary iota-toxin. Infect Immun, 69, 2980-7
Abstract
Busch C, Orth J, Djouder N, Aktories K (2001) Biological activity of a C-terminal fragment of Pasteurella multocida toxin. Infect Immun, 69, 3628-34
Abstract
Clerk A, Pham FH, Fuller SJ, Sahai E, Aktories K, Marais R, Marshall C, Sugden PH (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol, 21, 1173-84
Abstract
Djouder N, Schmidt G, Frings M, Cavalié A, Thelen M, Aktories K (2001) Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in FcεRI signaling in RBL 2H3 mast cells. J Immunol, 166, 1627-34
Abstract
Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M (2001) Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression. Eur J Immunol, 31, 1610-9
Abstract
Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H (2001) Characterization of the Enzymatic Component of the ADP-Ribosyltransferase Toxin CDTa from Clostridium difficile. Infect Immun, 69, 6004-11
Abstract
Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W (2001) An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem, 276, 20451-7
Abstract
Linseman DA, Laessig T, Meintzer MK, McClure M, Barth H, Aktories K, Heidenreich KA (2001) An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival. J Biol Chem, 276, 39123-31
Abstract
Schmidt G, Goehring UM, Schirmer J, Uttenweiler-Joseph S, Wilm M, Lohmann M, Giese A, Schmalzing G, Aktories K (2001) Lysine and polyamines are substrates for transglutamination of Rho by the Bordetella dermonecrotic toxin. Infect Immun, 69, 7663-70
Abstract
Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K (2001) Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress. Pflügers Arch, 442, 675-87
Abstract
Sorg I, Goehring UM, Aktories K, Schmidt G (2001) Recombinant Yersinia YopT leads to uncoupling of RhoA-effector interaction. Infect Immun, 69, 7535-43
Abstract
Tamma G, Klussmann E, Maric K, Aktories K, Svelto M, Rosenthal W, Valenti G (2001) The small GTP-binding protein Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells. Am J Physiol Renal Physiol, 281, 1092-101
Abstract
Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S (2001) Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci, 98, 3185-90
Abstract
Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I (2001) A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3. J Biol Chem, 276, 9537-42
Abstract
Reviews, Books
Wilde C, Aktories K (2001) The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases. Toxicon, 39, 1647-60
Abstract
2000 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Barth H, Blöcker D, Behlke J, Bergsma-Schutter W, Brisson A, Benz R, Aktories K (2000) Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification. J Biol Chem, 275, 18704-11
Abstract
Blöcker D, Barth H, Maier E, Benz R, Barbieri JT, Aktories K (2000) The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding. Infect Immun, 68, 4566-73
Abstract
Busch C, Hofmann F, Gerhard R, Aktories K (2000) Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J Biol Chem, 275, 13228-34
Abstract
Busch C, Schömig K, Hofmann F Aktories K (2000) Characterization of the catalytic domain of Clostridium novyi α-toxin. Infect Immun, 68, 6378-83
Abstract
Djouder N, Prepens U, Aktories K, Cavalié A (2000) Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells. J Biol Chem, 275, 18732-8
Abstract
Eckhardt M, Barth H, Blöcker D, Aktories K (2000) Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates. J Biol Chem, 275, 2328-34
Abstract
Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I (2000) New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization. Infect Immun, 68, 1094-101
Abstract
Gnad R, Aktories K, Kaina B, Fritz G (2000) Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress. Mol Pharmacol, 58, 1389-97
Abstract
Krall R, Schmidt G, Aktories K, Barbieri JT (2000) Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein. Infect Immun, 68, 6066-8
Abstract
Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brünig I, Aktories K, Nörenberg W (2000) Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: Evidence for a role of the small GTPase Rac1. J Neurosci, 20, 6743-51
Abstract
Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M (2000) The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci, 97, 5901-6
Abstract
von Pawel-Rammingen U, Telepnev MV, Schmidt G, Aktories K, Wolf-Watz H, Rosqvist R (2000) GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure. Mol Microbiol, 36, 737-48
Abstract
Wahl S, Barth H, Ciossek T, Aktories K, Mueller BK (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol, 149, 263-70
Abstract
Wilde C, Genth H, Aktories K, Just I (2000) Recognition of RhoA by Clostridium botulinum C3 exoenzyme. J Biol Chem, 275, 16478-83
Abstract
Reviews, Books
Aktories K (2000) Bacterial protein toxins as tools in cell biology and pharmacology. In: Cellular Microbiology. Cossart P, Boquet P, Normark S, Rappuoli R (eds.), ASM Press, Washington, 221-37.
Aktories K, Barth H, Just I (2000) Clostridium botulinum C3 exoenzyme and C3-like transferases. In: Bacterial Protein Toxins. Handbook of Experimental Pharmacologie. Aktories K, Just I (eds.), Springer Verlag, Berlin, 207-33.
Aktories K, Schmidt G, Just I (2000) Rho GTPases as targets of bacterial protein toxins. Biol Chem, 381, 421-6
Busch C, Aktories K (2000) Microbial toxins and the glycosylation of rho family GTPases. Curr Opin Struct Biol, 10, 528-35
Abstract
Just I, Boquet P (2000) Large clostridial cytotoxins as tools in cell biology. In: Clostridium difficile. Aktories K, Wilkins TD (eds.), Springer Verlag, Berlin.
Just I, Hofmann F, Aktories K (2000) Molecular mechanisms of action of the large clostridial cytotoxins. In: Bacterial Protein Toxins. Handbook of Experimental Pharmacologie. Aktories K, Just I (eds.), Springer Verlag, Berlin, 307-31.
AbstractJust I, Hofmann F, Aktories K (2000) Molecular mode of action of the large clostridial cytotoxins. In: Clostridium difficile. Aktories K, Wilkins TD (eds.), Springer Verlag, Berlin.
Lerm M, Schmidt G, Aktories K (2000) Bacterial protein toxins targeting Rho GTPases. FEMS Microbiol Lett, 188, 1-6
Abstract
Schmidt G, Aktories K (2000) Rho GTPase-activating toxins: cytotoxic necrotizing factors and dermonecrotic toxin. Methods Enzymol, 325, 125-36
Abstract
Schmidt G, Aktories K (2000) Purification and in vitro assays for bacterial toxins that activate Rho GTPases. In: Methods in Enzymology: Regulators and Effectors of Small GTPases. Balch WE, Der CJ, Hall A (eds.), Academic Press, San Diego, 125-36.
1999 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Barth H, Klingler M, Aktories K, Kinzel V (1999) Clostridium botulinum C2 toxin delays entry into mitosis and activation of p34cdc2 kinase and cdc25-C phosphatase in HeLa cells. Infect Immun, 67, 5083-90
Abstract
Barth H, Olenik C, Sehr P, Schmidt G, Aktories K, Meyer DK (1999) Neosynthesis and activation of Rho by Escherichia coli cytotoxic necrotizing factor (CNF1) reverse cytopathic effects of ADP-ribosylated Rho. J Biol Chem, 274, 27407-14
Abstract
Genth H, Aktories K, Just I (1999) Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem, 274, 29050-6
Abstract
Goehring UM, Schmidt G, Pederson KJ, Aktories K, Barbieri JT (1999) The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases. J Biol Chem, 274, 36369-72
Abstract
Lerm M, Schmidt G, Goehring UM, Schirmer J, Aktories K (1999) Identification of the region of Rho involved in substrate recognition by Escherichia coli cytotoxic necrotizing factor 1. J Biol Chem, 274, 28999-9004
Abstract
Lerm M, Selzer J, Hoffmeyer A, Rapp UR, Aktories K, Schmidt G (1999) Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect Immun, 67, 496-503
Abstract
Nilius B, Voets T, Prenen J, Barth H, Aktories K, Kaibuchi K, Droogmans G, Eggermont J (1999) Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. J Physiol (Lond.), 516, 67-74
Abstract
Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK (1999) Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA. Br J Pharmacol, 127, 1060-3
Abstract
Olenik C, Aktories K, Meyer DK (1999) Differential expression of the small GTP-binding proteins RhoA, RhoB, Cdc42u and Cdc42b in developing rat neocortex. Mol Brain Res, 70, 9-17
Abstract
Pederson KJ, Vallis AJ, Aktories K, Frank DW, Barbieri JT (1999) The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins. Mol Microbiol, 32, 393-401
Abstract
Rose F, Kürth-Landwehr C, Sibelius U, Reuner KH, Aktories K, Seeger W, Grimminger F (1999) Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells. Am J Respir Crit Care Med, 159, 206-12
Abstract
Schmidt G, Goehring UM, Schirmer J, Lerm M, Aktories K, (1999) Identification of the C-terminal part of Bordetella dermonecrotic toxin as a transglutaminase for rho GTPases. J Biol Chem, 274, 31875-81
Abstract
Reviews, Books
Aepfelbacher M, Aktories K (1999) Intra- und interzelluläre Strukturen. In: Pathophysiologie, Pathobiochemie. Pfreundschuh und Schölmerich (eds.), Urban & Fischer, 18-25.
Aktories K, Schmidt G, Hofmann F (1999) GTPases targetted by bacterial toxins. In: GTPases. Hall A (ed.), Oxford University Press, 311-31.
1998 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Barth H, Hofmann F, Olenik C, Just I, Aktories K (1998) The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun, 66, 1364-9
Abstract
Barth H, Preiss JC, Hofmann F, Aktories K (1998) Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis. J Biol Chem, 273, 29506-11
Abstract
Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I (1998) Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun, 66, 1755-8
Abstract
Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K (1998) A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem, 273, 19566-72
Abstract
Gerhard R, Schmidt G, Hofmann F, Aktories K (1998) Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun, 66, 5125-31
Abstract
Hofmann F, Busch C, Aktories K (1998) Chimeric clostridial cytotoxins: identification of the N-terminal region involved in proteine substrate recognition. Infect Immun, 66, 1076-81
Abstract
Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G (1998) Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J Physiol, 506, 83-93
Abstract
Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG (1998) Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin. Naunyn-Schmiedeberg's Arch Pharmacol, 357, 385-92
Abstract
Schmidt G, Selzer J, Lerm M, Aktories K (1998) The Rho-deamidating cytotoxic necrotizing factor 1 from Escherichia coli possesses transglutaminase activity. Cysteine 866 and histidine 881 are essential for enzyme activity. J Biol Chem, 273, 13669-74
Abstract
Prepens U, Barth H, Wilting J, Aktories K (1998) Influence of Clostridium botulinum C2 toxin on FcεRI-mediated secretion and tyrosine phosphorylation in RBL cells. Naunyn-Schmiedebergs Arch Pharmacol, 357, 323-30
Abstract
Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K (1998) Glucosylation and ADP ribosylation of Rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. Biochemistry, 37, 5296-304
Abstract
Tsakiridis T, Bergman A, Somwar R, Taha C, Aktories K, Cruz TF, Klip A, Downey GP (1998) Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression. J Biol Chem, 273, 28322-31
Abstract
Reviews, Books
Aktories K (1998) Bacterial toxins controlling Rho-GTPases. In: G proteins, cytoskeleton and cancer. Maruta H, Kohama K (eds.), RG. Landes Company, 343-54.
Aktories K (1998) How bacterial toxins affect the intestinal mucosa: molecular mechanism of the action of Clostridium difficile toxins. In: Gut and the liver. Blum HE, Bode Ch, Bode JCh, Sartor RB (eds.), Kluwer Academic Publishers, 185-94.
Schmidt G, Aktories K (1998) Bacterial Cytotoxins Target Rho GTPases. Naturwissenschaften, 85, 253-61.
1997 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Hofmann F, Busch C, Prepens U, Just I, Aktories K (1997) Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin. J Biol Chem, 272, 11074-8
Abstract
Koch G, Benz C, Schmidt G, Olenik C, Aktories K (1997) Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. J Pharmacol Exp Ther, 283, 901-9
Abstract
Kowluru A, Li G, Rabaglia ME, Segu VB, Hofmann F, Aktories K, Metz SA (1997) Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic β cells. Biochem Pharmacol, 54, 1097-108
Abstract
Olenik C, Barth H, Just I, Aktories K, Meyer DK (1997) Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain. Mol Brain Res, 52, 272-9
Abstract
Otto B, Steusloff A, Just I, Aktories K, Pfitzer G (1997) Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle. J Physiol (Lond.), 496, 317-29
Abstract
Schmidt G, Sehr P, Wilm M, Selzer J, Mann M, Aktories K (1997) Deamidation of Gln63 of Rho induced by Escherichia coli cytotoxic necrotizing factor 1. Nature, 387, 725-9
Abstract
Verschueren H, de Baetselier P, de Braekeleer J, Dewitt J, Aktories K, Just I (1997) ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. Eur J Cell Biol, 73, 182-7
Abstract
Wex CBA, Koch G, Aktories K (1997) Effects of Clostridium botulinum C2-toxin-induced depolymerisation of actin on degranulation of suspended and attached cells. Naunyn-Schmiedeberg's Arch Pharmacol, 355, 319-27
Abstract
Wex CBA, Koch G, Aktories K (1997) Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells. Naunyn-Schmiedeberg's Arch Pharmacol, 355, 328-34
Abstract
Reviews, Books
Aktories K (1997) Bacterial toxins that target Rho proteins. J Clin Invest, 99, 827-9
Abstract
Aktories K (1997) Modifikation von Rho-GTPasen durch bakterielle Toxine. Biospektrum, 6, 16-8.
Aktories K (1997) Rho proteins: targets for bacterial toxins and regulators of bacterial invasion. Trends Microbiol, 5, 282-8
Abstract
Aktories K (1997) Rho-Proteine: Molekulare Schalter und Substrate bakterieller Toxine. Glukosylierung von Rho-Proteinen durch Clostridium difficile Toxine. DGPT-Forum, 22-8.
Aktories K, Koch G (1997) Clostridium botulinum ADP-ribosyltransferase C3. In: Bacterial Toxins. Aktories K (ed.), Chapman & Hall, Weinheim, 61-9.
Aktories K, Sehr P, Just I (1997) Actin-ADP-ribosylating toxins: Cytotoxic mechanism of Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. In: Bacterial Toxins. Aktories K (ed.), Chapman & Hall, Weinheim, 93-101.
Aktories K, Selzer J, Hofmann F, Just I (1997) Molecular mechanism of Clostridium difficile toxin A and B. In: Molecular Genetics and Pathogenesis of the Clostridia. Rodd J, Songer G, McClane B, Titball R (eds.), Academic Press , London, 393-407.
Aktories K, Prepens U, Sehr P, Just I (1997) Probing the actin cytoskeleton by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. In: Bacterial Toxins. Aktories K (ed.), Chapman & Hall, Weinheim, 129-39.
Bacterial Toxins. Aktories K (ed.) (1997) Chapman & Hall, Weinheim.
Just I, Selzer J, Hofmann K, Aktories K (1997) Clostridium difficile toxin B as a probe for Rho GTPases. In: Bacterial Toxins. Aktories K (ed.), Chapman & Hall, Weinheim, 159-68.
1996 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995...
Böhmer J, Jung M, Sehr P, Fritz G, Popoff M, Just I, Aktories K (1996) Active site mutation of the C3-like ADP-ribosyltransferase from Clostridium limosum - Analysis of glutamic acid 174. Biochemistry, 35, 282-9
Abstract
Geipel U, Just I, Aktories K (1996) ADP-ribosylation of an ~70 kDa protein of Klebsiella pneumoniae. Infect Immun, 64, 1720-3
Abstract
Genth H, Hofmann F, Selzer J, Rex G, Aktories K, Just I (1996) Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii. Biochem Biophys Res Commun, 229, 370-4
Abstract
Hofmann F, Rex G, Aktories K, Just I (1996)The Ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin. Biochem Biophys Res Commun, 227, 77-81
Abstract
Just I, Selzer J, Hofmann F, Green GA, Aktories K (1996) Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation. J Biol Chem, 271, 10149-53
Abstract
Prepens U, Just I, von Eichel-Streiber C, Aktories K (1996) Inhibition of FcεRI-mediated activation of RBL cells by Clostridium difficile toxin B (mono-glucosyltransferase). J Biol Chem, 271, 7324-9
Abstract
Sehr P, Just I, Aktories K (1996) ADP-ribosylation of actin by Clostridium perfringens iota toxin and turkey erythrocyte ADP-ribosyltransferase A: Effects on profilin-regulated nucleotide exchange and ATPase activity. Naunyn-Schmiedeberg's Arch Pharmacol, 354, 693-7
Abstract
Selzer J, Hofmann F, Rex G, Wilm M, Mann M, Just I, Aktories K (1996) Clostridium novyi a-toxin catalyzed incorporation of GlcNAc into Rho subfamily proteins. J Biol Chem, 271, 25173-7
Abstract
van Damme J, Jung M, Hofmann F, Just I, Vandekerckhove J, Aktories K (1996) Analysis of the catalytic site of the actin ADP-ribosylating Clostridium perfringens iota toxin. FEBS Lett, 380, 291-5
Abstract
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Fritz G, Kaina B, Aktories K (1995) The Ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA-damaging treatments. J Biol Chem, 270, 25172-7
Abstract
Fritz G, Schroeder P, Aktories K (1995) Isolation and characterization of Clostridium botulinum C2 toxin-resistant cell line: Evidence for a possible involvement of the cellular C2II-receptor in growth regulation. Infect Immun, 63, 2334-40
Abstract
Just I, Sehr P, Jung M, van Damme H, Puype M, Vandekerckhove J, Moss J, Aktories K (1995) ADP-ribosyltransferase type A from turkey erythrocytes modifies actin at Arg-95 and Arg-372. Biochemistry, 34, 326-33
Abstract
Just I, Selzer J, Jung M, van Damme J, Vandekerckhove,J, Aktories K (1995) Rho-ADP-ribosylating exoenzyme from Bacillus cereus -purification, characterization and identification of the NAD-binding site. Biochemistry, 34,334-40
Abstract
Just I, Selzer J, von Eichel-Streiber C, Aktories K (1995) The low-molecular-mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile. J Clin Invest, 95, 1026-31
Abstract
Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature, 375, 500-3
Abstract
Just I, Wilm M, Selzer J, Rex G, von Eichel-Streiber C, Mann M, Aktories K (1995) The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J Biol Chem, 270, 13932-6
Abstract
Melamed I, Turner CE, Aktories K, Kaplan DR, Gelfand EW (1995) Nerve Growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes. J Exp Med, 181, 1071-9
Abstract
Schmalzing G, Richter HP, Hansen H, Aktories K (1995) Involvement of the GTP-binding protein Rho in endocytosis of Xenopus oocytes. J Cell Biol, 130, 1319-32
Abstract
Fritz G, Aktories K (1994) ADP-ribosylation of Rho protein by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors. Biochem J, 300, 133-9
Abstract
Just I, Fritz G, Aktories K, Giry M, Popoff MR, Boquet P, Hegenbarth S, von Eichel-Streiber C (1994) Clostridium difficile toxin B acts on the GTP-binding protein Rho. J Biol Chem, 269, 10706-12
Abstract
Just I, Wollenberg P, Moss J, Aktories K (1994) Cysteine-specific ADP-ribosylation of actin. Eur J Biochem, 221, 1047-54
Abstract
Schmid A, Benz R, Just I, Aktories K (1994) Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes: Formation of cation-selective channels and inhibition of channel function by chloroquine. J Biol Chem, 269, 16706-11
Abstract
Jung M, Just I, van Damme J, Vandekerckhove J, Aktories K (1993) NAD-binding site of the C3-like ADP-ribosyltransferase from Clostridium limosum. J Biol Chem, 268, 23215-18
Abstract
Just I, Hennessey ES, Drummond DR, Aktories K, Sparrow JC (1993) ADP-ribosylation of Drosophila indirect flight muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin. Biochem J, 291, 409-12
Abstract
Just I, Wille M, Chaponnier C, Aktories K (1993) Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils. Eur J Pharmacol, 246, 293-7
Abstract
Just I, Mohr C, Schallehn G, Menard L, Didsbury JR, Vandekerckhove J, van Damme J, Aktories K (1992) Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum. J Biol Chem, 267, 10274-80
Abstract
Wille M, Just I, Wegner A, Aktories K (1992) ADP-ribosylation of the gelsolin-actin complex by clostridial toxins. J Biol Chem, 267, 50-5
Abstract
Grimminger F, Sibelius U, Aktories K, Just I, Seeger W (1991) Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction. J Biol Chem, 266, 19276-82
Abstract
Suttorp N, Polley M, Seybold J, Schnittler H, Seeger W, Grimminger F, Aktories K (1991) Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. J Clin Invest, 87, 1575-84
Abstract
Wiegers W, Just I, Müller H, Hellwig A, Traub P, Aktories K (1991) Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase. Eur J Cell Biol, 54, 237-45
Abstract
Paterson HF, Self AJ, Garrett MD, Just I, Aktories K, Hall A (1990) Microinjection of recombinant p21Rho induces rapid changes in cell morphology. J Cell Biol, 111, 1001-7
Abstract
Aktories K, Bärmann M, Ohishi I, Tsuyama S, Jakobs KH, Habermann E (1986) Botulinum C2 toxin ADP-ribosylates actin. Nature, 322, 390-2
Abstract
Reviews, Books
Aktories K, Just I (1995) In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases. In: Small GTPases and their Regulators. Balch WE, Der CJ, Hall A (eds.), Methods in Enzymology, 256, 184-95.
Aktories K, Just I (1995) Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins. Trends Cell Biol, 5, 441-3.
Aktories K, Just I (1995) Studies on the active site structure of C3-like exoenzymes: Involvement of glutamic acid in catalysis of ADP-ribosylation. Biochimie, 77, 326-32
Abstract
Aktories K, Koch G (1995) Modification of actin and of Rho proteins by clostridial ADP-ribosylating toxins. In: Handbook of Natural Toxins, Volume 8: Microbial Toxins. Iglewski B, Moss J, Tu AT, Vaughan M (eds.), 491-520.
AbstractAktories K (1994) Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins. Mol Cell Biochem, 138, 167-76